The primer bulb has a diaphragm in the bulb. If it’s not sealing and you elevating the end is required to relieve the air, then the diaphragm is not sealing. Granted that air pushed into the lines with it flat or even down, though it should still seal and that air is existing in the line to push out either way. It should run uphill to the VST (fuel pump) and press through either way.